ITGB5 Gene Summary [Human]
This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | ITGB5 |
| Official Name | integrin subunit beta 5 [Source:HGNC Symbol;Acc:HGNC:6160] |
| Ensembl ID | ENSG00000082781 |
| Bio databases IDs | |
| Aliases | integrin subunit beta 5 |
| Synonyms | [b]-5, [b]5A, [b]5B, beta-5, Beta5 integrin, ESTM23, integrin beta 5, Integrin Beta X, integrin subunit beta 5, integrin subunit β 5, Integrin β 5, Integrin β X, RGD1563276, β-5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ITGB5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin beta chain VWA domain
- Integrin plexin domain
- protein binding
- receptor binding
- Integrin beta subunits (N-terminal portion of extracellular region)
- Integrin beta tail domain
- Integrin beta cytoplasmic domain
- PAK4 binding membrane proximal domain
- cytoplasmic domain
- vWFA
- integrin binding
- cytosolic tail domain
- Integrin beta epidermal growth factor like domain 1
Pathways
Biological processes and signaling networks where the ITGB5 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- Integrin Signaling
- Macropinocytosis Signaling
- PAK Signaling
- Paxillin Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- non-insulin-dependent diabetes mellitus
- hypertension
- lung squamous cell carcinoma
- squamous cell lung cancer
- dextran sodium sulfate-induced colitis
- tumor
- peritoneal endometriosis
role in cell
- expression in
- growth
- proliferation
- phosphorylation in
- activation in
- colony formation
- number
- migration
- cell death
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell surface
- cellular membrane
- focal adhesions
- synaptic membrane
- cell membrane leading edge
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ITGB5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- cell-matrix adhesion
- cell adhesion mediated by integrin
- integrin-mediated signaling pathway
- epithelial cell-cell adhesion
- transforming growth factor beta receptor signaling pathway
- endodermal cell differentiation
- stress fiber assembly
- wound healing, spreading of epidermal cells
- cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- alphav-beta5 integrin complex
- phagocytic vesicle
- receptor complex
- integrin complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- viral receptor activity
- integrin binding