RNF157 Gene Summary [Human]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of signal transduction; positive regulation of dendrite extension; and protein autoubiquitination. Predicted to be located in cell body. Predicted to be active in early endosome; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RNF157 |
| Official Name | ring finger protein 157 [Source:HGNC Symbol;Acc:HGNC:29402] |
| Ensembl ID | ENSG00000141576 |
| Bio databases IDs | |
| Aliases | ring finger protein 157 |
| Synonyms | 2610036E23RIK, A130073L17Rik, mKIAA1917, ring finger protein 157 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF157 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- Ring finger domain
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
role in cell
- apoptosis
- expression in
- cell death
- differentiation
- extension
- binding in
- ubiquitination in
- degradation in
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF157 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cell body
Molecular Function
What the gene product does at the molecular level
- metal ion binding