GEMIN7 Gene Summary [Human]
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GEMIN7 |
| Official Name | gem nuclear organelle associated protein 7 [Source:HGNC Symbol;Acc:HGNC:20045] |
| Ensembl ID | ENSG00000142252 |
| Bio databases IDs | |
| Aliases | gem nuclear organelle associated protein 7 |
| Synonyms | 2400008I04Rik, gem (nuclear organelle) associated protein 7, gem nuclear organelle associated protein 7, SIP3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GEMIN7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sm and related proteins
- protein binding
- Gem-associated protein 7 (Gemin7)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- gems
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GEMIN7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spliceosomal snRNP assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- SMN-Sm protein complex
- cytosol
- SMN complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding