STRAP Gene Summary [Human]
Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of transforming growth factor beta receptor signaling pathway; and spliceosomal snRNP assembly. Located in cytosol. Part of SMN complex. Implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | STRAP |
| Official Name | serine/threonine kinase receptor associated protein [Source:HGNC Symbol;Acc:HGNC:30796] |
| Ensembl ID | ENSG00000023734 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase receptor associated protein, Unr-interacting protein, mitogen-activated protein kinase activator with WD repeats, MAPK activator with WD repeats |
| Synonyms | LOC100910575, MAWD, PT-WD, serine/threonine kinase receptor associated protein, UNRIP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STRAP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- C-terminal regulatory domain
- mRNA binding
- ribonucleoprotein binding
- WD domain, G-beta repeat
- WD40
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic epilepsy
role in cell
- apoptosis
- activation in
- phosphorylation in
- differentiation
- cell viability
- binding in
- growth
- alternative splicing by
- assembly in
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- Cytoplasm
- Nucleus
- cytosol
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STRAP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- neuron differentiation
- alternative nuclear mRNA splicing, via spliceosome
- maintenance of gastrointestinal epithelium
- negative regulation of transforming growth factor beta receptor signaling pathway
- spliceosomal snRNP assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- SMN-Sm protein complex
- cytosol
- SMN complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA binding
- receptor binding