STK24 Gene Summary [Human]
This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Details
| Type | Protein Coding |
| Official Symbol | STK24 |
| Official Name | serine/threonine kinase 24 [Source:HGNC Symbol;Acc:HGNC:11403] |
| Ensembl ID | ENSG00000102572 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 24, STE20-like kinase 3, sterile 20-like kinase 3 |
| Synonyms | 1810013H02RIK, C76483, HEL-S-95, LOC108349348, MST-3, MST3B, RGD1561742, serine/threonine kinase 24, STE20, STK3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- regulatory domain
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- precursor B-cell acute lymphoblastic leukemia
- chronic phase chronic myeloid leukemia
- metabolic disorder
- major depression
- nonalcoholic fatty liver disease
- obesity
- liver cancer
- non-small cell lung cancer
role in cell
- phosphorylation in
- expression in
- apoptosis
- activation in
- proliferation
- quantity
- accumulation in
- degradation in
- migration
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Golgi Apparatus
- lipid droplets
- cytosol
- Golgi membrane
- nucleoplasm
- nucleoli
- nerve ending
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of axon regeneration
- signal transduction
- induction of apoptosis by oxidative stress
- regulation of axon regeneration
- cellular response to oxidative stress
- protein autophosphorylation
- cellular response to starvation
- protein phosphorylation
- execution phase of apoptosis
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- Golgi membrane
- Golgi apparatus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- cadherin binding
- protein kinase activity
- protein serine/threonine kinase activity