Pgd Gene Summary [Mouse]
Enables phosphogluconate dehydrogenase (decarboxylating) activity. Involved in pentose-phosphate shunt, oxidative branch. Acts upstream of or within pentose biosynthetic process. Is active in cytosol. Is expressed in several structures, including adrenal gland; alimentary system; axial musculature; liver; and orbito-sphenoid. Orthologous to human PGD (phosphogluconate dehydrogenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgd |
| Official Name | phosphogluconate dehydrogenase [Source:MGI Symbol;Acc:MGI:97553] |
| Ensembl ID | ENSMUSG00000028961 |
| Bio databases IDs | |
| Aliases | phosphogluconate dehydrogenase |
| Synonyms | 0610042A05Rik, 6PGD, 6PGDH, Cc2-27, LOC100363662, phosphogluconate dehydrogenase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pgd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 6-phosphogluconate dehydrogenase (decarboxylating)
- Rossmann-fold NAD(P)(+)-binding proteins
- binding protein
- NADP binding
- phosphogluconate 2-dehydrogenase
- NAD binding domain of 6-phosphogluconate dehydrogenase
- 6-phosphogluconate dehydrogenase, C-terminal domain
- phosphogluconate dehydrogenase (decarboxylating)
- enzyme
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- psoriasis
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- androgenic alopecia
- actinic keratosis
- acute myocardial infarction
- primary prostate cancer
regulates
- D-glucose
- fructose-6-phosphate
- PGD dimer
- CYBB
- glucose-6-phosphate
- reactive oxygen species
- lipid
- ribulose 5-phosphate
- NADPH
- D-ribose-5-phosphate
role in cell
- growth
- expression in
- proliferation
- cell viability
- cell death
- accumulation in
- oxygen consumption rate
- biosynthesis in
- pentose shunt in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Nucleus
- microtubule organizing centers
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pgd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pentose-phosphate shunt, oxidative branch
- pentose-phosphate shunt
- D-gluconate catabolic process
- pentose biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- NADP binding
- phosphogluconate dehydrogenase (decarboxylating) activity