PSMD10 Gene Summary [Human]
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | PSMD10 |
| Official Name | proteasome 26S subunit, non-ATPase 10 [Source:HGNC Symbol;Acc:HGNC:9555] |
| Ensembl ID | ENSG00000101843 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, non-ATPase 10, gankyrin |
| Synonyms | dJ889N15.2, Gankyrin, p28, p28Gank, p28(GANK), proteasome 26S subunit, non-ATPase 10, proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMD10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- transcription factor binding
- protein binding
- LXCXE binding site
- Ankyrin repeat
- ankyrin repeats
Pathways
Biological processes and signaling networks where the PSMD10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- Parkinson disease
- cholangiocarcinoma cancer
- liver cancer
- bile duct cancer
- liver neoplasia
- biliary tract cancer
- epithelial cancer
- abdominal cancer
role in cell
- growth
- apoptosis
- quantity
- phosphorylation in
- expression in
- migration
- turnover
- epithelial-mesenchymal transition
- invasion
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- intermediate filament cytoskeleton
- cilia
- Nucleus
- cytosol
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMD10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cyclin-dependent protein kinase activity
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- negative regulation of release of cytochrome c from mitochondria
- cytoplasmic sequestering of NF-kappaB
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of MAPK cascade
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of cell growth
- negative regulation of apoptotic process
- proteasome regulatory particle assembly
- apoptotic process
- positive regulation of protein ubiquitination
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- intermediate filament cytoskeleton
- proteasome regulatory particle, base subcomplex
- cytoplasm
- cytosol
- proteasome complex
- neuron projection
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription factor binding
- cytoskeletal protein binding
- ion channel binding
- protein binding, bridging