RAD18 Gene Summary [Human]
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RAD18 |
| Official Name | RAD18 E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:18278] |
| Ensembl ID | ENSG00000070950 |
| Bio databases IDs | |
| Aliases | RAD18 E3 ubiquitin protein ligase |
| Synonyms | 2810024C04Rik, hHR18, hRAD18, RAD18 E3 ubiquitin protein ligase, Rad18sc, RNF73 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAD18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- DNA repair protein rad18
- SAP motif
- Rad18-like CCHC zinc finger
- SAP domain
- Rad6-binding domain
- DNA secondary structure binding
- Ring finger domain
- protein binding
- identical protein binding
- DNA polymerase eta binding domain
- binding protein
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Takayasu arteritis
- organismal death
- uterine leiomyoma
- leiomyomatosis
- wheeze
role in cell
- proliferation
- expression in
- accumulation in
- phosphorylation in
- survival
- cell death
- number
- radiosensitivity
- activation in
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- centrosome
- nuclear foci
- nucleoplasm
- nuclear bodies
- sex chromatin
- chromatin
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAD18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of chromosome segregation
- DNA repair
- response to DNA damage stimulus
- protein monoubiquitination
- postreplication repair
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- replication fork
- nuclear inclusion body
- nucleus
- centrosome
- site of double-strand break
- nuclear body
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- metal ion binding
- polyubiquitin binding
- Y-form DNA binding
- damaged DNA binding
- single-stranded DNA binding