IGSF3 Gene Summary [Human]
The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD). [provided by RefSeq, Jun 2016]
Details
| Type | Protein Coding |
| Official Symbol | IGSF3 |
| Official Name | immunoglobulin superfamily member 3 [Source:HGNC Symbol;Acc:HGNC:5950] |
| Ensembl ID | ENSG00000143061 |
| Bio databases IDs | |
| Aliases | immunoglobulin superfamily member 3 |
| Synonyms | 1700016K10RIK, 2810035F16Rik, 4833439O17Rik, EWI-3, immunoglobulin superfamily member 3, immunoglobulin superfamily, member 3, LCDD, mKIAA0466, V8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGSF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGSF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lacrimal gland development
Cellular Component
Where in the cell the gene product is active
- membrane
- cell surface