Igsf3 Gene Summary [Mouse]

Predicted to be involved in lacrimal gland development. Predicted to be active in membrane. Is expressed in dorsal root ganglion; lung; and spinal cord. Human ortholog(s) of this gene implicated in lacrimal duct obstruction. Orthologous to human IGSF3 (immunoglobulin superfamily member 3). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Retained Intron
Official Symbol
Igsf3
Official Name
immunoglobulin superfamily, member 3 [Source:MGI Symbol;Acc:MGI:1926158]
Ensembl ID
ENSMUSG00000042035
Bio databases IDs NCBI: 78908 Ensembl: ENSMUSG00000042035
Aliases immunoglobulin superfamily, member 3
Synonyms 1700016K10RIK, 2810035F16Rik, 4833439O17Rik, EWI-3, immunoglobulin superfamily member 3, immunoglobulin superfamily, member 3, LCDD, mKIAA0466, V8
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igsf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Immunoglobulin V-Type
  • immunoglobulin domain
  • Immunoglobulin like
  • Immunoglobulin V-set domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • angioimmunoblastic T-cell lymphoma
  • T-cell non-Hodgkin disease
  • mature T-cell neoplasia
  • lacrimal duct defect
regulated by
regulates

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Igsf3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • lacrimal gland development

Cellular Component

Where in the cell the gene product is active
  • membrane
  • cell surface

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.