Xpr1 Gene Summary [Mouse]
Enables virus receptor activity. Acts upstream of or within response to virus. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; extraembryonic component; lower jaw molar; neural retina; and placenta. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human XPR1 (xenotropic and polytropic retrovirus receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Xpr1 |
| Official Name | xenotropic and polytropic retrovirus receptor 1 [Source:MGI Symbol;Acc:MGI:97932] |
| Ensembl ID | ENSMUSG00000026469 |
| Bio databases IDs | |
| Aliases | xenotropic and polytropic retrovirus receptor 1 |
| Synonyms | IBGC6, LOC108353304, Rmc-1, SLC53A1, Sxv, SYG1, X3, xenotropic and polytropic retrovirus receptor 1, XR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Xpr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Syg1, Pho81, XPR1, and related proteins
- inorganic phosphate transporter
- binding protein
- efflux permease
- viral receptor
- EXS family
- SPX domain
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic basal ganglia calcification type 6
- FeCl3 induced thrombosis
- pulmonary embolism
- infection by Xenotropic MuLV-related virus
- infection by mink cell focus-forming virus
role in cell
- proliferation
- cell death
- apoptosis
- cell viability
- phosphorylation in
- expression in
- production in
- sphere formation
- invasion by
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Xpr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- phosphate ion transport
- cellular response to phosphate starvation
- response to virus
- phosphate ion transmembrane transport
- cellular phosphate ion homeostasis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- inorganic phosphate transmembrane transporter activity
- efflux transmembrane transporter activity
- inositol hexakisphosphate binding
- viral receptor activity