AQP10

AQP10 Gene Summary

This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]

Details

Type
Processed Transcript
Official Symbol
AQP10
Official Name
aquaporin 10 [Source:HGNC Symbol;Acc:HGNC:16029]
Ensembl ID
ENSG00000143595
Bio databases IDs NCBI: 89872 Ensembl: ENSG00000143595
Aliases aquaporin 10
Synonyms
AQPA HUMAN,aquaporin 10
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • MIP
  • glycerol channel
  • protein binding
  • water channel
  • transporter

Pathways

Biological processes and signaling networks where the AQP10 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • CUL3
  • PLP1
  • GPR37L1
  • GPR152
  • CISD2
  • CYBC1
  • ERGIC3
  • PVR
  • MGST3
  • LMNA
disease
  • non-insulin-dependent diabetes mellitus
  • metabolic syndrome X
regulated by
  • isoproterenol
regulates
  • glycerol
  • water
role in cell
  • permeability

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • intracellular membrane-bounded organelle
  • cellular membrane
  • apical membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the AQP10 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • water transport
  • protein homotetramerization
  • glycerol transport
  • urea transmembrane transport
  • cellular response to acidity
  • response to toxin

CELLULAR COMPONENT

Where in the cell the gene product is active
  • lipid particle
  • intracellular membrane-bounded organelle
  • basolateral plasma membrane
  • plasma membrane
  • apical plasma membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • protein binding
  • glycerol channel activity
  • water channel activity
  • urea transmembrane transporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.