GPR37L1
GPR37L1 Gene Summary
Enables G protein-coupled peptide receptor activity; peptide binding activity; and prosaposin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and positive regulation of MAPK cascade. Located in plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GPR37L1 |
| Official Name | G protein-coupled receptor 37 like 1 [Source:HGNC Symbol;Acc:HGNC:14923] |
| Ensembl ID | ENSG00000170075 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 37 like 1 |
| Synonyms | CAG-18,D0Kist8,ET(B)R-LP-2,ETBR-LP-2,Gpcr 37-like 1,G protein-coupled receptor 37-like 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- peptide binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPR37L1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GPR37
- DYRK1A
- PTCH1
- THSD7B
- AP2M1
- RNF122
- prosaptide d1
- UBC
- CD46
- ARL13B
disease
- neoplasia
- cancer
- hydrocephalus
- hypersensitive reaction
- astrocytosis
- central nervous system cancer
- head and neck cancer
- brain cancer
- head and neck neoplasia
- diverticular disease
regulated by
- S100A8
- prosaptide d1
- S100A9
- PRCP
- LPA
regulates
- ERK1/2
- SMO
- EIF4E
- SHH
- MYCN
- GLI2
- PTCH1
role in cell
- differentiation
- proliferation
- phosphorylation in
- maturation
- abnormal morphology
- response by
- cell survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- basal membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GPR37L1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- Bergmann glial cell differentiation
- negative regulation of systemic arterial blood pressure
- negative regulation of neuron differentiation
- positive regulation of cerebellar granule cell precursor proliferation
- negative regulation of astrocyte differentiation
- smoothened signaling pathway
- positive regulation of MAPK cascade
- negative regulation of smoothened signaling pathway
- cellular response to reactive oxygen species
CELLULAR COMPONENT
Where in the cell the gene product is active
- membrane
- cilium membrane
- receptor complex
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- protein binding
- peptide binding