MGST3 Gene Summary [Human]
This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
Details
| Type | Protein Coding |
| Official Symbol | MGST3 |
| Official Name | microsomal glutathione S-transferase 3 [Source:HGNC Symbol;Acc:HGNC:7064] |
| Ensembl ID | ENSG00000143198 |
| Bio databases IDs | |
| Aliases | microsomal glutathione S-transferase 3, microsomal glutathione S-transferase III, microsomal GST-3, microsomal GST-III |
| Synonyms | 2010012L10RIK, 2010306B17Rik, 2700004G04RIK, AA516734, GST-3, GST-III, Loc289197, microsomal glutathione S-transferase 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MGST3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glutathione transferase
- MAPEG family
- enzyme
- protein binding
- glutathione peroxidase
- leukotriene-C4 synthase
- identical protein binding
Pathways
Biological processes and signaling networks where the MGST3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- progressive familial intrahepatic cholestasis type 1
role in cell
- expression in
- phosphorylation in
- production in
- molecular cleavage in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MGST3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukotriene biosynthetic process
- prostanoid metabolic process
- lipid metabolic process
- arachidonic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- glutathione peroxidase activity
- glutathione transferase activity
- leukotriene-C4 synthase activity