LIMD1 Gene Summary [Human]
Predicted to enable transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; regulation of gene expression; and response to hypoxia. Acts upstream of or within P-body assembly and gene silencing by miRNA. Located in several cellular components, including P-body; adherens junction; and focal adhesion. Part of RISC complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | LIMD1 |
| Official Name | LIM domains containing 1 [Source:HGNC Symbol;Acc:HGNC:6612] |
| Ensembl ID | ENSG00000144791 |
| Bio databases IDs | |
| Aliases | LIM domains containing 1, LIM domain containing 1 |
| Synonyms | D9Ertd192e, LIM domain containing 1, LIM domains containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LIMD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PreLIM domain
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- transcription co-repressor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- hepatocellular carcinoma
- doxorubicin induced cardiotoxicity
- liver cancer
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- Dupuytren contracture
- overall survival
role in cell
- quantity
- activation in
- expression in
- assembly
- differentiation
- development
- function
- organization
- abnormal number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic mRNA processing body
- Cytoplasm
- focal adhesions
- Plasma Membrane
- cytosol
- nucleoplasm
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LIMD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- negative regulation of hippo signaling cascade
- negative regulation of translation involved in gene silencing by miRNA
- cytoskeleton organization
- gene silencing by miRNA
- regulation of transcription, DNA-dependent
- osteoblast development
- negative regulation of osteoblast differentiation
- negative regulation of canonical Wnt receptor signaling pathway
- response to hypoxia
- negative regulation of transcription, DNA-dependent
- cytoplasmic mRNA processing body assembly
- phosphorylation
- cell migration
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- adherens junction
- focal adhesion
- cytoplasm
- cytoplasmic mRNA processing body
- cytosol
- RNA-induced silencing complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- transcription corepressor activity