IL17RD Gene Summary [Human]
This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | IL17RD |
| Official Name | interleukin 17 receptor D [Source:HGNC Symbol;Acc:HGNC:17616] |
| Ensembl ID | ENSG00000144730 |
| Bio databases IDs | |
| Aliases | interleukin 17 receptor D, similar expression to fgf genes |
| Synonyms | 2810004A10RIK, HH18, IL17RLM, interleukin 17 receptor D, mSef, RGD1565237, SEF, Sef-S |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL17RD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- transmembrane domain
- SEFIR domain
- intracellular domain
- protein binding
- N-terminus of interleukin 17 receptor D
Pathways
Biological processes and signaling networks where the IL17RD gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- epithelial neoplasia
- non-small cell lung cancer
- epithelial cancer
- delayed puberty
- susceptibility to Kallmann syndrome type 18
- soft tissue sarcoma cancer
- lung adenocarcinoma formation
- non-squamous non-small cell lung cancer
role in cell
- activation in
- expression in
- apoptosis
- proliferation
- phosphorylation in
- binding in
- differentiation
- signaling in
- response
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- Golgi membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL17RD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epithelial to mesenchymal transition
- cytokine-mediated signaling pathway
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- interleukin-17 receptor activity