MED12L Gene Summary [Human]
The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]
Details
| Type | Processed Transcript |
| Official Symbol | MED12L |
| Official Name | mediator complex subunit 12L [Source:HGNC Symbol;Acc:HGNC:16050] |
| Ensembl ID | ENSG00000144893 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 12L |
| Synonyms | A130035F20, A630079M02, LOC682481, mediator complex subunit 12L, mediator complex subunit 12-like, NIZIDS, NOPAR, RGD1304617, TNRC11L, TRALP, TRALPUSH |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MED12L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Eukaryotic Mediator 12 catenin-binding domain
- Eukaryotic Mediator 12 subunit domain
- transcription factor binding
- protein binding
- OPA domain
- Transcription mediator complex subunit Med12
Pathways
Biological processes and signaling networks where the MED12L gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MED12L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- mediator complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- transcription factor binding
- beta-catenin binding