EAF2 Gene Summary [Human]
Enables transcription elongation regulator activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of transcription elongation from RNA polymerase II promoter. Part of transcription elongation factor complex. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | EAF2 |
| Official Name | ELL associated factor 2 [Source:HGNC Symbol;Acc:HGNC:23115] |
| Ensembl ID | ENSG00000145088 |
| Bio databases IDs | |
| Aliases | ELL associated factor 2 |
| Synonyms | BM-040, ELL associated factor 2, Festa, FESTA-L, FESTA-S, TRAITS, U19 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EAF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
- RNA polymerase II transcription elongation factor
- transcriptional elongation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- non-small cell lung cancer
- cancer
- liver neoplasia
- lymphomagenesis
- B cell cancer
- B-cell neoplasia
- hematologic cancer
- lymphoid cancer
role in cell
- apoptosis
- proliferation
- expression in
- phosphorylation in
- accumulation in
- growth
- stabilization in
- migration
- invasion by
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EAF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epithelial cell proliferation involved in prostate gland development
- regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of cell growth
- apoptotic process
- epithelial cell proliferation involved in prostate gland development
- positive regulation of transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription elongation factor complex
- nuclear speck
- ELL-EAF complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription elongation regulator activity
- protein binding