TM4SF19 Gene Summary [Human]

The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

Details

Type
Protein Coding
Official Symbol
TM4SF19
Official Name
transmembrane 4 L six family member 19 [Source:HGNC Symbol;Acc:HGNC:25167]
Ensembl ID
ENSG00000145107
Bio databases IDs NCBI: 116211 Ensembl: ENSG00000145107
Aliases transmembrane 4 L six family member 19
Synonyms EG277203, OCTM4, RGD1560486, transmembrane 4 L six family member 19
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TM4SF19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • L6 membrane protein
  • protein homodimerization
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • epithelial cancer
  • liver cancer
  • androgenic alopecia
  • colon adenocarcinoma
  • colon epithelial cancer
  • chronic obstructive pulmonary disease
  • renal clear cell adenocarcinoma
  • renal clear cell cancer
  • hepatocellular carcinoma
  • urothelial bladder carcinoma
regulated by
  • cholesterol
  • SMARCA4
  • MAP2K1
  • fluticasone propionate
  • 10E,12Z-octadecadienoic acid
role in cell
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • actin cytoskeleton
  • filopodia

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TM4SF19 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.