TNS2 Gene Summary [Human]
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TNS2 |
| Official Name | tensin 2 [Source:HGNC Symbol;Acc:HGNC:19737] |
| Ensembl ID | ENSG00000111077 |
| Bio databases IDs | |
| Aliases | tensin 2 |
| Synonyms | C1-TEN, KIAA1075, nep, nph, TENC1, tensin 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein-tyrosine-phoshatase
- enzyme
- PTP_DSP_cys
- protein binding
- receptor binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- identical protein binding
- kinase binding
- protein kinase C conserved region 1 (C1 domain) superfamily
- C2 domain of PTEN tumour-suppressor protein
- Src homology 2 (SH2) domain
Pathways
Biological processes and signaling networks where the TNS2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine serous papillary cancer
- preeclampsia
regulates
- Collagen(s)
role in cell
- migration
- growth
- proliferation
- apoptosis
- homeostasis
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- focal adhesions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- cellular homeostasis
- response to muscle activity
- kidney development
- negative regulation of cell proliferation
- multicellular organismal homeostasis
- peptidyl-tyrosine dephosphorylation
- negative regulation of insulin receptor signaling pathway
- collagen metabolic process
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein tyrosine phosphatase activity
- metal ion binding
- lipid binding
- kinase binding