STX7 Gene Summary [Human]
The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]
Details
| Type | Protein Coding |
| Official Symbol | STX7 |
| Official Name | syntaxin 7 [Source:HGNC Symbol;Acc:HGNC:11442] |
| Ensembl ID | ENSG00000079950 |
| Bio databases IDs | |
| Aliases | syntaxin 7 |
| Synonyms | Clone 24889 mRNA Sequence, LOC100910446, Syn7, syntaxin 7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STX7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- SNAP receptor
- Syntaxin-like protein
- protein binding
- chloride channel inhibitor activity
- syntaxin binding
- SynN
- binding protein
- cytoplasmic domain
- SNARE domain
- Helical region found in SNAREs
- transmembrane domain
- SNARE motif
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenomyosis
- localized cutaneous leishmaniasis
regulates
role in cell
- fusion
- growth
- exocytosis
- localization
- assembly
- fusion in
- growth in
- cytotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- synaptic vesicle membrane
- perinuclear region
- endosomes
- vesicles
- lysosome
- membrane compartment
- immunological synapses
- mitochondrial outer membrane
- lysosome membrane
- endosomal membrane
- synaptic vesicles
- growth cone
- neurites
- recycling endosomes
- early endosomes
- late endosomes
- endocytotic vesicle
- azurophil granules
- secretory granules
- perikaryon
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STX7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organelle localization
- organelle assembly
- vesicle fusion
- vesicle docking
- positive regulation of T cell mediated cytotoxicity
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- late endosome
- lysosomal membrane
- plasma membrane
- immunological synapse
- lysosome
- early endosome membrane
- endocytic vesicle
- early endosome
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- endosome
- azurophil granule
- endomembrane system
- SNARE complex
- vesicle
- tertiary granule
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- chloride channel inhibitor activity
- protein binding
- syntaxin binding
- SNAP receptor activity
- SNARE binding