TENM2 Gene Summary [Human]
Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and retrograde trans-synaptic signaling by trans-synaptic protein complex. Located in cell-cell junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TENM2 |
| Official Name | teneurin transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:29943] |
| Ensembl ID | ENSG00000145934 |
| Bio databases IDs | |
| Aliases | teneurin transmembrane protein 2 |
| Synonyms | 2610040L17RIK, 9330187F13RIK, LOC102551468, ODZ2, Odz3, TEN2, teneurin transmembrane protein 2, TNM2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TENM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- RHS repeat-associated core domain
- cell adhesion molecule binding
- Keratin, high sulfur B2 protein
- protein binding
- receptor binding
- NHL repeat unit of beta-propeller proteins
- identical protein binding
- Family of unknown function (DUF5885)
- EGF_CA
- GHH signature containing HNH/Endo VII superfamily nuclease toxin
- Delta serrate ligand
- YD repeat (two copies)
- protein homodimerization
- Teneurin Intracellular Region
- RHS Repeat
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- insomnia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- cannabis dependence
- Huntington disease
- schizophrenia
- major depression
- androgenic alopecia
- rib fracture
role in cell
- innervation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell junction
- synaptic cleft
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- postsynaptic membrane
- dendritic spines
- growth cone
- neurites
- synapse
- filopodia
- PML nuclear bodies
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TENM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- signal transduction
- heterophilic cell-cell adhesion
- positive regulation of filopodium assembly
- neuron development
Cellular Component
Where in the cell the gene product is active
- PML body
- endoplasmic reticulum
- Golgi apparatus
- synapse
- neuron projection
- plasma membrane
- growth cone
- dendrite
- nucleus
- postsynaptic membrane
- dendritic spine
- cell junction
- filopodium
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein heterodimerization activity
- calcium ion binding
- cell adhesion molecule binding