TLK1 Gene Summary [Human]
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | TLK1 |
| Official Name | tousled like kinase 1 [Source:HGNC Symbol;Acc:HGNC:11841] |
| Ensembl ID | ENSG00000198586 |
| Bio databases IDs | |
| Aliases | tousled like kinase 1 |
| Synonyms | 4930545J15Rik, LOC103690017, PKU-beta, PKU-β, SNAK, Tlk1 predicted, tousled-like kinase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TLK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the TLK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- pervasive developmental disorder
- chronic lymphocytic leukemia
- mucoepidermoid carcinoma
- salivary duct carcinoma
- salivary duct cancer
- acinar-cell carcinoma
role in cell
- organization
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TLK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromosome segregation
- chromatin organization
- protein phosphorylation
- intracellular protein transport
- response to DNA damage stimulus
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity