CALML5 Gene Summary [Human]
This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CALML5 |
| Official Name | calmodulin like 5 [Source:HGNC Symbol;Acc:HGNC:18180] |
| Ensembl ID | ENSG00000178372 |
| Bio databases IDs | |
| Aliases | calmodulin like 5, calmodulin-like skin protein |
| Synonyms | Calm4, calmodulin-like 5, CLSP |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CALML5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- EF-hand domain pair
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- calcium ion binding
- EFh
- protein binding
- EFh_MICU
- EFh_PI-PLC
Pathways
Biological processes and signaling networks where the CALML5 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Apelin Endothelial Signaling Pathway
- Autophagy
- Calcium Signaling
- CCR3 Signaling in Eosinophils
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- eNOS Signaling
- fMLP Signaling in Neutrophils
- Glioma Signaling
- Glutamate Receptor Signaling
- GP6 Signaling Pathway
- IL-12 Signaling and Production in Macrophages
- iNOS Signaling
- Melatonin Signaling
- nNOS Signaling in Neurons
- nNOS Signaling in Skeletal Muscle Cells
- Nur77 Signaling in T Lymphocytes
- PI3K Signaling in B Lymphocytes
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Synaptic Long Term Potentiation
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- detergent resistant lipid raft fraction
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CALML5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- epidermis development
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- enzyme regulator activity