SPRR1B Gene Summary [Human]
The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-rich and contains several tandem amino acid repeats. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | SPRR1B |
| Official Name | small proline rich protein 1B [Source:HGNC Symbol;Acc:HGNC:11260] |
| Ensembl ID | ENSG00000169469 |
| Bio databases IDs | |
| Aliases | small proline rich protein 1B, cornifin-B |
| Synonyms | CORNIFIN, cornifin B, GADD33, small proline-rich protein 1B, SPR-IB, SPRR1, SQ37 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPRR1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cornifin (SPRR) family
- structural constituent of cytoskeleton
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- perinuclear region
- Golgi Apparatus
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPRR1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinocyte differentiation
- epidermis development
- peptide cross-linking
- keratinization
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- structural molecule activity