CHMP7 Gene Summary [Human]
Involved in several processes, including late endosome to vacuole transport; midbody abscission; and mitotic nuclear division. Located in cytosol; nuclear envelope; and nucleoplasm. Part of ESCRT III complex. Colocalizes with chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CHMP7 |
| Official Name | charged multivesicular body protein 7 [Source:HGNC Symbol;Acc:HGNC:28439] |
| Ensembl ID | ENSG00000147457 |
| Bio databases IDs | |
| Aliases | charged multivesicular body protein 7 |
| Synonyms | 4930596K11RIK, 6330407G04Rik, AK016398, charged multivesicular body protein 7, RGD1308779 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHMP7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PTZ00464
- protein binding
- Snf7
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- midbody
- cytosol
- lysosome membrane
- nuclear pores
- nucleoplasm
- nuclear envelope
- autophagic vacuoles
- multivesicular bodies
- kinetochore microtubule
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHMP7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- protein transport
- late endosome to vacuole transport
- nucleus organization
- membrane budding
- non-lytic virus budding from plasma membrane
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- plasma membrane repair
- protein localization to chromatin
- autophagy
- multivesicular body sorting pathway
- exit from mitosis
- nuclear envelope reassembly
- mitotic metaphase plate congression
- late endosome to vacuole transport via multivesicular body sorting pathway
- vesicle fusion with vacuole
Cellular Component
Where in the cell the gene product is active
- ESCRT III complex
- kinetochore
- multivesicular body
- chromatin
- autophagic vacuole membrane
- lysosomal membrane
- plasma membrane
- internal side of plasma membrane
- nuclear pore
- nucleoplasm
- nuclear envelope
- kinetochore microtubule
- cytosol
- multivesicular body membrane
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding