Chmp7 Gene Summary [Mouse]
Predicted to be involved in several processes, including midbody abscission; mitotic nuclear division; and vacuolar transport. Predicted to be located in several cellular components, including bounding membrane of organelle; chromosome; and nucleus. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in cytoplasmic side of plasma membrane and multivesicular body. Is expressed in several structures, including branchial arch; facial prominence; heart; limb bud; and neural fold. Orthologous to human CHMP7 (charged multivesicular body protein 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Chmp7 |
| Official Name | charged multivesicular body protein 7 [Source:MGI Symbol;Acc:MGI:1913922] |
| Ensembl ID | ENSMUSG00000034190 |
| Bio databases IDs | |
| Aliases | charged multivesicular body protein 7 |
| Synonyms | 4930596K11RIK, 6330407G04Rik, AK016398, charged multivesicular body protein 7, RGD1308779 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chmp7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PTZ00464
- protein binding
- Snf7
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- midbody
- cytosol
- lysosome membrane
- nuclear pores
- nucleoplasm
- nuclear envelope
- autophagic vacuoles
- multivesicular bodies
- kinetochore microtubule
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chmp7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- protein transport
- late endosome to vacuole transport
- nucleus organization
- membrane budding
- non-lytic virus budding from plasma membrane
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- plasma membrane repair
- protein localization to chromatin
- autophagy
- multivesicular body sorting pathway
- exit from mitosis
- nuclear envelope reassembly
- mitotic metaphase plate congression
- late endosome to vacuole transport via multivesicular body sorting pathway
- vesicle fusion with vacuole
Cellular Component
Where in the cell the gene product is active
- ESCRT III complex
- kinetochore
- multivesicular body
- chromatin
- autophagic vacuole membrane
- lysosomal membrane
- plasma membrane
- internal side of plasma membrane
- nuclear pore
- nucleoplasm
- nuclear envelope
- kinetochore microtubule
- cytosol
- multivesicular body membrane
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding