REXO4 Gene Summary [Human]
Enables DNA binding activity and nuclease activity. Involved in DNA catabolic process, endonucleolytic; DNA catabolic process, exonucleolytic; and DNA repair. Located in nuclear speck and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | REXO4 |
| Official Name | REX4 homolog, 3'-5' exonuclease [Source:HGNC Symbol;Acc:HGNC:12820] |
| Ensembl ID | ENSG00000148300 |
| Bio databases IDs | |
| Aliases | REX4 homolog, 3'-5' exonuclease |
| Synonyms | Gm111, PMC2, REX4, REX4, 3'-5' exonuclease, REX4 homolog, 3'-5' exonuclease, XPMC2, XPMC2H |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human REXO4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endonuclease
- 3'-5' exonuclease
- transcription regulator
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- single-stranded DNA binding
- double-stranded DNA binding
- exonuclease
- EXOIII
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human REXO4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA catabolic process
- regulation of transcription, DNA-dependent
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 3'-5' exonuclease activity
- protein binding
- RNA binding
- exonuclease activity
- endonuclease activity
- double-stranded DNA binding
- single-stranded DNA binding