SAA4
SAA4 Gene Summary
Predicted to be involved in acute-phase response. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SAA4 |
| Official Name | serum amyloid A4, constitutive [Source:HGNC Symbol;Acc:HGNC:10516] |
| Ensembl ID | ENSG00000148965 |
| Bio databases IDs | |
| Aliases | serum amyloid A4, constitutive |
| Synonyms | C-SAA,Saa-5,serum amyloid A 4,serum amyloid A4, constitutive |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Serum amyloid A protein
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the SAA4 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- KLK10
- GJA1
- UBE2U
- APOC1
- APOA1
- CIDEB
- APOA2
- APOD
- SAA1
disease
- COVID-19
- breast cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- Staphylococcus aureus pneumonia
- autosomal dominant polycystic kidney disease
regulated by
- calmodulin
- IL1B
- dexamethasone
- IL1
- cholesterol
- elaidic acid
- EHF
- ADAM10
- IL6
- TO-901317
regulates
- triacylglycerol
- very low density lipoprotein (VLDL)
- HDL
role in cell
- regulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SAA4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- acute-phase response
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- high-density lipoprotein particle
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding