KAT14 Gene Summary [Human]

CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

Details

Type
Protein Coding
Official Symbol
KAT14
Official Name
lysine acetyltransferase 14 [Source:HGNC Symbol;Acc:HGNC:15904]
Ensembl ID
ENSG00000149474
Bio databases IDs NCBI: 57325 Ensembl: ENSG00000149474
Aliases lysine acetyltransferase 14, cysteine rich protein 2 binding protein, ATAC component 2 homolog (Drosophila)
Synonyms 2510008M08Rik, ATAC2, CRP2BP, CSRP2BP, D2Ertd473e, D2Wsu131e, dJ717M23.1, E430020F17, lysine acetyltransferase 14, PRO1194
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KAT14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • histone acetyltransferase
  • NAT_SF
  • Acetyltransferase (GNAT) domain
  • enzyme
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • metastasis
  • organismal death
  • cervical cancer
regulated by
regulates
  • histone H4
  • CDH1
  • RNA polymerase II
  • CDH2
  • DNA promoter
  • DNA endogenous promoter
  • N-cadherin
role in cell
  • proliferation
  • expression in
  • acetylation in
  • migration
  • cell cycle progression
  • transactivation in
  • cisplatin resistance
  • invasion by
  • G2/M phase transition

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human KAT14 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of transcription from RNA polymerase II promoter
  • regulation of cell division
  • chromatin remodeling
  • regulation of tubulin deacetylation
  • regulation of embryonic development
  • regulation of transcription, DNA-dependent
  • regulation of cell cycle
  • regulation of transcription from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • mitotic spindle
  • cytoplasm
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • histone acetyltransferase activity
  • protein binding
  • LIM domain binding

Gene-Specific Assays for Results You Can Trust

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