PEAK1 Gene Summary [Human]
This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
Details
| Type | Protein Coding |
| Official Symbol | PEAK1 |
| Official Name | pseudopodium enriched atypical kinase 1 [Source:HGNC Symbol;Acc:HGNC:29431] |
| Ensembl ID | ENSG00000173517 |
| Bio databases IDs | |
| Aliases | pseudopodium enriched atypical kinase 1 |
| Synonyms | 1110049L02Rik, 9530046P14, AA690169, C230081A13Rik, KIAA2002, mKIAA2002, pseudopodium-enriched atypical kinase 1, RGD1312026, SG269, SGK269 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PEAK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- Kinase regulatory loop binding domain
- non-membrane spanning protein tyrosine kinase
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the PEAK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- colon cancer
- inflammatory bowel disease
- refractive error
- prostate cancer
- metabolic syndrome X
- malocclusion
- otosclerosis
- prostatic intraepithelial neoplasm
role in cell
- phosphorylation in
- growth
- migration
- binding in
- assembly
- assembly in
- cell spreading
- disassembly in
- regulation in
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- focal adhesions
- actin cytoskeleton
- actin filaments
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PEAK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of focal adhesion assembly
- substrate adhesion-dependent cell spreading
- protein autophosphorylation
- focal adhesion assembly
- protein phosphorylation
- cell migration
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- actin cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- protein kinase activity