Kat14 Gene Summary [Mouse]
Predicted to enable histone acetyltransferase activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Acts upstream of or within G2/M transition of mitotic cell cycle. Located in nucleus. Part of ATAC complex. Is expressed in embryo and extraembryonic component. Orthologous to human KAT14 (lysine acetyltransferase 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kat14 |
| Official Name | lysine acetyltransferase 14 [Source:MGI Symbol;Acc:MGI:1917264] |
| Ensembl ID | ENSMUSG00000027425 |
| Bio databases IDs | |
| Aliases | lysine acetyltransferase 14 |
| Synonyms | 2510008M08Rik, ATAC2, CRP2BP, CSRP2BP, D2Ertd473e, D2Wsu131e, dJ717M23.1, E430020F17, lysine acetyltransferase 14, PRO1194 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kat14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone acetyltransferase
- NAT_SF
- Acetyltransferase (GNAT) domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- organismal death
- cervical cancer
regulated by
- Org 2058
- SMAD4
role in cell
- proliferation
- expression in
- acetylation in
- migration
- cell cycle progression
- transactivation in
- cisplatin resistance
- invasion by
- G2/M phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kat14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell division
- chromatin remodeling
- regulation of tubulin deacetylation
- regulation of embryonic development
- regulation of transcription, DNA-dependent
- regulation of cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase activity
- protein binding
- LIM domain binding