ESAM
ESAM Gene Summary
Enables cell-cell adhesion mediator activity. Involved in several processes, including bicellular tight junction assembly; cell-cell adhesion; and regulation of actin cytoskeleton organization. Located in cell-cell junction and plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ESAM |
| Official Name | endothelial cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:17474] |
| Ensembl ID | ENSG00000149564 |
| Bio databases IDs | |
| Aliases | endothelial cell adhesion molecule |
| Synonyms | 2310008D05Rik,endothelial cell adhesion molecule,endothelial cell-specific adhesion molecule,Epithelial cell-specific adhesion molecule,Esam1,HIPC,NEDIHSS,W117m |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- Immunoglobulin V-Type
- immunoglobulin domain
- cell adhesion molecule binding
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the ESAM gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SLC30A9
- MAGI1
- KIF14
- CENPF
- ENG
- ESAM
- TOP1
- MDC1
- MPHOSPH8
- C3orf52
disease
- schizophrenia
- neurodevelopmental disorder with intracranial hemorrhage, seizures and spasticity
- lung adenocarcinoma
- lung adenocarcinoma formation
regulated by
- GCG
- MYB
- desmopressin
- PTH
- TGFB1
- KRAS
- CALCA
- CREBBP
- N6AMT1
- DLL4
regulates
- RAS homolog
role in cell
- migration
- adhesion
- assembly
- aggregation
- organization
- polymerization
- tubulation
- extravasation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- button-like junction
- cell surface
- cellular membrane
- intercellular junctions
- anchoring junction
- tight junctions
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ESAM gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
- regulation of actin cytoskeleton organization
- tight junction assembly
- protein localization
- homophilic cell adhesion
- maintenance of blood-brain barrier
CELLULAR COMPONENT
Where in the cell the gene product is active
- tight junction
- adherens junction
- cell-cell junction
- macromolecular complex
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding