Esam Gene Summary [Mouse]
Predicted to enable cell-cell adhesion mediator activity. Acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Located in adherens junction; bicellular tight junction; and plasma membrane. Is expressed in several structures, including cardiovascular system; liver; lung; nervous system; and placenta. Orthologous to human ESAM (endothelial cell adhesion molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Esam |
| Official Name | endothelial cell-specific adhesion molecule [Source:MGI Symbol;Acc:MGI:1916774] |
| Ensembl ID | ENSMUSG00000001946 |
| Bio databases IDs | |
| Aliases | endothelial cell-specific adhesion molecule |
| Synonyms | 2310008D05Rik, endothelial cell adhesion molecule, endothelial cell-specific adhesion molecule, Epithelial cell-specific adhesion molecule, Esam1, HIPC, NEDIHSS, W117m |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Esam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- Immunoglobulin V-Type
- immunoglobulin domain
- cell adhesion molecule binding
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neurodevelopmental disorder with intracranial hemorrhage, seizures and spasticity
- lung adenocarcinoma
- lung adenocarcinoma formation
regulates
- RAS homolog
role in cell
- migration
- adhesion
- assembly
- aggregation
- organization
- polymerization
- tubulation
- extravasation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- button-like junction
- cell surface
- cellular membrane
- intercellular junctions
- anchoring junction
- tight junctions
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Esam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
- regulation of actin cytoskeleton organization
- tight junction assembly
- protein localization
- homophilic cell adhesion
- maintenance of blood-brain barrier
Cellular Component
Where in the cell the gene product is active
- tight junction
- adherens junction
- cell-cell junction
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding