DSN1 Gene Summary [Human]

This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

Details

Type
Protein Coding
Official Symbol
DSN1
Official Name
DSN1 component of MIS12 kinetochore complex [Source:HGNC Symbol;Acc:HGNC:16165]
Ensembl ID
ENSG00000149636
Bio databases IDs NCBI: 79980 Ensembl: ENSG00000149636
Aliases DSN1 component of MIS12 kinetochore complex, kinetochore null 3 homolog (C. elegans)
Synonyms 1700022L09Rik, C20orf172, dJ469A13.2, DSN1 component of MIS12 kinetochore complex, DSN1 homolog, MIS12 kinetochore complex component, hKNL-3, KNL3, MIS13, Q9H410
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DSN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Mis12-Mtw1 protein family
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hallux valgus
  • nonsyndromic cleft lip and palate
regulated by
role in cell
  • assembly
  • segregation
  • proliferation by
  • segregation in
  • misalignment in
  • misalignment

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • fibrillar center
  • azurophil granule lumen
  • Extracellular Space
  • cytosol
  • nucleoplasm
  • nucleoli
  • nuclear bodies
  • kinetochores

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human DSN1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell division
  • attachment of spindle microtubules to kinetochore
  • satellite cell proliferation

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • nuclear body
  • spindle pole
  • cytosol
  • kinetochore
  • nucleolus
  • extracellular region
  • MIS12/MIND type complex
  • azurophil granule lumen
  • fibrillar center
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.