NAAA Gene Summary [Human]
Enables N-(long-chain-acyl)ethanolamine deacylase activity; N-acylsphingosine amidohydrolase activity; and fatty acid amide hydrolase activity. Involved in several processes, including N-acylethanolamine metabolic process; N-acylphosphatidylethanolamine metabolic process; and sphingosine metabolic process. Located in lysosome. Is extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NAAA |
| Official Name | N-acylethanolamine acid amidase [Source:HGNC Symbol;Acc:HGNC:736] |
| Ensembl ID | ENSG00000138744 |
| Bio databases IDs | |
| Aliases | N-acylethanolamine acid amidase |
| Synonyms | 2210023K21RIK, 3830414F09Rik, ASAHL, N-acylethanolamine acid amidase, N-acylethanolamine-hydrolyzing acid amidase, PLT |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NAAA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- N-(long-chain-acyl)ethanolamine deacylase
- fatty acid amide hydrolase
- beta subunit of N-acylethanolamine-hydrolyzing acid amidase
- Non-peptide carbon-nitrogen bond hydrolase
- transcription factor binding
- enzyme
- ceramidase
- Linear amide C-N hydrolases, choloylglycine hydrolase family
Pathways
Biological processes and signaling networks where the NAAA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- active ulcerative colitis
- colon cancer
role in cell
- cellular infiltration by
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- lysosome
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NAAA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- N-acylphosphatidylethanolamine metabolic process
- sphingosine metabolic process
- lipid catabolic process
- N-acylethanolamine metabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- lysosomal lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
- ceramidase activity
- fatty acid amide hydrolase activity
- N-(long-chain-acyl)ethanolamine deacylase activity