TADA3 Gene Summary [Human]
DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Details
| Type | Protein Coding |
| Official Symbol | TADA3 |
| Official Name | transcriptional adaptor 3 [Source:HGNC Symbol;Acc:HGNC:19422] |
| Ensembl ID | ENSG00000171148 |
| Bio databases IDs | |
| Aliases | transcriptional adaptor 3, alteration/deficiency in activation 3 |
| Synonyms | 1110004B19Rik, ADA3, ADA3L, hADA3, NGG1, STAF54, TADA3L, transcriptional adaptor 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TADA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ligand-dependent nuclear receptor interactor
- transcription co-activator
- Histone acetyltransferases subunit 3
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- binding in
- apoptosis
- expression in
- proliferation
- cell cycle progression
- missegregation
- cell proliferation
- acetylation in
- missegregation in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- mitotic spindle
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TADA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of DNA repair
- regulation of embryonic development
- regulation of tubulin deacetylation
- regulation of transcription, DNA-dependent
- chromatin organization
- mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell division
- regulation of protein stability
- regulation of protein phosphorylation
- positive regulation of transcription, DNA-dependent
- regulation of RNA splicing
- positive regulation of gene expression
- regulation of cell cycle
- intracellular estrogen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- transcription factor TFTC complex
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- protein domain specific binding
- protein binding
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity