MCRS1 Gene Summary [Human]
Enables RNA binding activity and telomerase inhibitor activity. Involved in histone H4 acetylation; negative regulation of DNA metabolic process; and positive regulation of protein localization to nucleolus. Located in cytoplasm; nucleolus; and nucleoplasm. Part of Ino80 complex; MLL1 complex; and histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MCRS1 |
| Official Name | microspherule protein 1 [Source:HGNC Symbol;Acc:HGNC:6960] |
| Ensembl ID | ENSG00000187778 |
| Bio databases IDs | |
| Aliases | microspherule protein 1, INO80 complex subunit Q |
| Synonyms | ICP22BP, INO80Q, MCRS2, Microspherule protein 1, MSP58, P78 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MCRS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- FHA domain
- enzyme inhibitor activity
- N-terminal region of micro-spherule protein
- dynein intermediate chain binding
- Forkhead associated domain
- protein binding
- single-stranded RNA binding
- forkhead associated (FHA) domain superfamily
- RNA binding
- poly(U) binding protein
Pathways
Biological processes and signaling networks where the MCRS1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal neoplasm
- renal neoplasia
- epithelial cancer
- colorectal neoplasia
- gastrointestinal neoplasia
- stomach neoplasm
- neoplasia
- colon neoplasm
- pancreatic carcinoma
- pancreatic epithelial cancer
role in cell
- expression in
- phosphorylation in
- activation in
- proliferation
- apoptosis
- transformation
- senescence
- premature senescence
- cell cycle progression
- flattening
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- nucleoplasm
- nucleoli
- nuclear bodies
- spindle pole
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MCRS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- protein modification process
- DNA repair
- regulation of DNA strand elongation
- regulation of chromosome organization
- regulation of DNA repair
- DNA recombination
- regulation of embryonic development
- telomere maintenance
- regulation of DNA replication
- positive regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- cytoplasm
- Ino80 complex
- nucleolus
- perikaryon
- NSL complex
- MLL1 complex
- histone acetyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- poly(G) RNA binding
- G-quadruplex RNA binding
- poly(U) RNA binding