Vps26b

Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and retrograde transport, endosome to Golgi. Acts upstream of or within cellular response to type II interferon. Located in early endosome; late endosome; and phagocytic vesicle. Part of retromer complex. Is active in glutamatergic synapse; postsynaptic early endosome; and postsynaptic recycling endosome. Is expressed in several structures, including central nervous system; dorsal root ganglion; male reproductive system; sensory organ; and urinary system. Orthologous to human VPS26B (VPS26 retromer complex component B). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps26b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps26b gene, providing context for its role in the cell.