ZNF827 Gene Summary [Human]
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNF827 |
| Official Name | zinc finger protein 827 [Source:HGNC Symbol;Acc:HGNC:27193] |
| Ensembl ID | ENSG00000151612 |
| Bio databases IDs | |
| Aliases | zinc finger protein 827 |
| Synonyms | 2810449M09RIK, D630040G17Rik, LOC152485, RGD1560620, Zfp827, zinc finger protein 827 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF827 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- binding protein
- C2H2-type zinc-finger domain
- Zinc-finger double domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- hypertension
- prostatic intraepithelial neoplasia
- prostate cancer
- coronary artery disease
- dermatological disorder
- preeclampsia
- gout
- alcoholic liver disease
- fibromuscular dysplasia
role in cell
- maintenance
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF827 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- establishment of protein localization to telomere
- telomere maintenance
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding