Zfp827 Gene Summary [Mouse]
Predicted to enable NuRD complex binding activity. Predicted to be involved in several processes, including establishment of protein localization to telomere; negative regulation of shelterin complex assembly; and regulation of DNA-templated transcription. Predicted to be located in chromatin and chromosome, telomeric region. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Orthologous to human ZNF827 (zinc finger protein 827). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp827 |
| Official Name | zinc finger protein 827 [Source:MGI Symbol;Acc:MGI:2444807] |
| Ensembl ID | ENSMUSG00000071064 |
| Bio databases IDs | |
| Aliases | zinc finger protein 827 |
| Synonyms | 2810449M09RIK, D630040G17Rik, LOC152485, RGD1560620, Zfp827, zinc finger protein 827 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp827 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- binding protein
- C2H2-type zinc-finger domain
- Zinc-finger double domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- hypertension
- prostatic intraepithelial neoplasia
- prostate cancer
- coronary artery disease
- dermatological disorder
- preeclampsia
- gout
- alcoholic liver disease
- fibromuscular dysplasia
role in cell
- maintenance
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp827 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- establishment of protein localization to telomere
- telomere maintenance
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding