CORO1C Gene Summary [Human]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Details

Type
Protein Coding
Official Symbol
CORO1C
Official Name
coronin 1C [Source:HGNC Symbol;Acc:HGNC:2254]
Ensembl ID
ENSG00000110880
Bio databases IDs NCBI: 23603 Ensembl: ENSG00000110880
Aliases coronin 1C
Synonyms COR1C, coronin 1C, coronin, actin binding protein 1C, CRN2, HCRNN4, RGD1564490
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CORO1C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Anaphase-promoting complex subunit 4 WD40 domain
  • actin filament binding
  • Type of WD40 repeat
  • WD40 repeats
  • enzyme binding
  • WD domain, G-beta repeat
  • WD40
  • protein binding
  • Domain of unknown function (DUF1899)

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • gastric cancer
  • thrombocytosis
  • Marfan syndrome
  • coronary artery disease
  • endometrial cancer
  • infection by Influenza A virus subtype H1N1
regulated by
role in cell
  • apoptosis
  • expression in
  • proliferation
  • invasion by
  • migration
  • phagocytosis by
  • organization
  • tubulation
  • sprouting by
  • migration by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • plasma membrane fraction
  • soluble fraction
  • endoplasmic reticulum fraction
  • mitochondrial fraction
  • detergent resistant lipid raft fraction
  • cytoskeleton
  • cilia
  • perinuclear region
  • cortical rim
  • actin cytoskeleton
  • Plasma Membrane
  • vesicles
  • cell-cell contacts
  • plasma membrane projections
  • lateral plasma membrane
  • endosomal membrane
  • cell membrane leading edge
  • lamellipodia
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CORO1C gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • membrane fission
  • signal transduction
  • positive regulation of lamellipodium morphogenesis
  • negative regulation of substrate adhesion-dependent cell spreading
  • regulation of substrate adhesion-dependent cell spreading
  • negative regulation of protein kinase activity by regulation of protein phosphorylation
  • actin filament organization
  • regulation of ruffle assembly
  • corpus callosum development
  • ventricular system development
  • establishment of protein localization
  • negative regulation of focal adhesion assembly
  • regulation of focal adhesion assembly
  • neural crest cell migration
  • regulation of protein phosphorylation
  • negative regulation of protein phosphorylation
  • phagocytosis
  • endosomal transport
  • negative regulation of epithelial cell migration
  • regulation of epithelial cell migration
  • regulation of fibroblast migration

Cellular Component

Where in the cell the gene product is active
  • lateral plasma membrane
  • synapse
  • focal adhesion
  • sarcolemma
  • cell cortex
  • actin cytoskeleton
  • vesicle
  • ruffle membrane
  • endosome membrane
  • sarcomere
  • lamellipodium
  • flotillin complex

Molecular Function

What the gene product does at the molecular level
  • actin filament binding
  • protein binding
  • small GTPase binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.