CNOT6 Gene Summary [Human]
This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | CNOT6 |
| Official Name | CCR4-NOT transcription complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:14099] |
| Ensembl ID | ENSG00000113300 |
| Bio databases IDs | |
| Aliases | CCR4-NOT transcription complex subunit 6 |
| Synonyms | A230103N10RIK, CCR4, CCR4A, CCR4-NOT transcription complex subunit 6, CCR4-NOT transcription complex, subunit 6, KIAA1194, RGD1310783 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CNOT6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- poly(A)-specific ribonuclease
- transcription co-activator
- exoribonuclease
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- Leucine rich repeat
- enzyme
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- gastric adenocarcinoma
- gastric epithelial cancer
role in cell
- proliferation
- expression in
- formation
- assembly
- Gap 0-Gap 1 phase
- formation in
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CNOT6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- positive regulation of transcription, DNA-dependent
- positive regulation of cytoplasmic mRNA processing body assembly
- positive regulation of cell proliferation
- mRNA cleavage involved in gene silencing by miRNA
- nuclear-transcribed mRNA catabolic process, no-go decay
- nuclear-transcribed mRNA poly(A) tail shortening
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- CCR4-NOT complex
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- protein binding
- RNA binding
- metal ion binding
- ligand-dependent nuclear receptor transcription coactivator activity
- exoribonuclease activity