RASGRP3 Gene Summary [Human]
The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | RASGRP3 |
| Official Name | RAS guanyl releasing protein 3 [Source:HGNC Symbol;Acc:HGNC:14545] |
| Ensembl ID | ENSG00000152689 |
| Bio databases IDs | |
| Aliases | RAS guanyl releasing protein 3, calcium- and diacylglycerol-regulated guanine nucleotide exchange factor III |
| Synonyms | CALDAG-GEFIII, Gm327, GRP3, RAS guanyl releasing protein 3, RAS, guanyl releasing protein 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RASGRP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- protein kinase C conserved region 1 (C1 domain) superfamily
- EF-hand domain pair
- guanyl-nucleotide exchange factor
- enzyme binding
- EFh
- GTPase activator
- protein binding
- RasGEF
- REM
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- chronic obstructive pulmonary disease
- castration refractory prostate cancer
- Sjögren syndrome
- systemic lupus erythematosus
- peripheral arterial disease
- multiple system atrophy
- epithelial cancer
- thoracic aortic aneurysms and dissections
- lip and oral cavity carcinoma
role in cell
- proliferation
- number
- blockade
- migration
- development
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RASGRP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- small GTPase mediated signal transduction
- Ras protein signal transduction
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- guanyl-nucleotide exchange factor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity
- diacylglycerol binding
- small GTPase binding
- kinase binding