IFIT5 Gene Summary [Human]
Enables nucleic acid binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in actin cytoskeleton; apical part of cell; and ruffle membrane. Colocalizes with IkappaB kinase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | IFIT5 |
| Official Name | interferon induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol;Acc:HGNC:13328] |
| Ensembl ID | ENSG00000152778 |
| Bio databases IDs | |
| Aliases | interferon induced protein with tetratricopeptide repeats 5, retinoic acid- and interferon-inducible protein (58kD) |
| Synonyms | IFI58, interferon induced protein with tetratricopeptide repeats 5, ISG58, P58, Retinoic acid- and IFN-inducible protein, 58 kD, RI58 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFIT5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- RNA cap binding
- double-stranded DNA binding
- Tetratricopeptide repeats
- protein binding
- tetratricopeptide repeat
- single-stranded RNA binding
- RNA binding
- poly(U) binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- actin cytoskeleton
- cytosol
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFIT5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- defense response to virus
- negative regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- apical part of cell
- IkappaB kinase complex
- actin cytoskeleton
- ruffle membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- single-stranded RNA binding
- double-stranded DNA binding
- RNA cap binding
- poly(U) RNA binding
- tRNA binding