MAST1 Gene Summary [Human]
This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017]
Details
| Type | Protein Coding |
| Official Symbol | MAST1 |
| Official Name | microtubule associated serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:19034] |
| Ensembl ID | ENSG00000105613 |
| Bio databases IDs | |
| Aliases | microtubule associated serine/threonine kinase 1 |
| Synonyms | 9430008B02Rik, KIAA0973, MCCCHCM, microtubule associated serine/threonine kinase 1, SAST, SAST170 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAST1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- ATP binding
- canonical PDZ domain
- protein binding
- magnesium ion binding
- Protein kinase domain
- PDZ domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- microtubule binding
- Protein Kinases, catalytic domain
- Domain of unknown function (DUF1908)
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations
- metabolic syndrome X
- urothelial bladder carcinoma
- transitional cell bladder cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung squamous cell carcinoma
role in cell
- phosphorylation in
- cisplatin resistance
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- cellular membrane
- Nucleus
- Plasma Membrane
- acrosome
- neurites
- microsomal membrane
- membrane processes
- perikaryon
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAST1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- brain development
- protein phosphorylation
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoskeleton
- cytoplasm
- neuronal cell body
- neuron projection
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity
- microtubule binding