MED21 Gene Summary [Human]
This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | MED21 |
| Official Name | mediator complex subunit 21 [Source:HGNC Symbol;Acc:HGNC:11473] |
| Ensembl ID | ENSG00000152944 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 21 |
| Synonyms | 0610007L03Rik, D6Ertd782e, hSrb7, MED17, mediator complex subunit 21, SRB7, SURB7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MED21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Subunit 21 of Mediator complex
- transcription regulator
- transcription co-activator
- ubiquitin protein ligase activity
- protein binding
Pathways
Biological processes and signaling networks where the MED21 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- androgenic alopecia
- Huntington disease
- metastasis
- peripheral arterial disease
regulates
- DNA endogenous promoter
- DNA promoter
- RNA polymerase II
- mediator
role in cell
- replication in
- autophagy
- autophagy in
- binding in
- cell viability
- cell death
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MED21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- blastocyst development
- somatic stem cell maintenance
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- ubiquitin ligase complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- protein binding
- DNA-directed RNA polymerase activity
- transcription coactivator activity