POLR2B Gene Summary [Human]
This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | POLR2B |
| Official Name | RNA polymerase II subunit B [Source:HGNC Symbol;Acc:HGNC:9188] |
| Ensembl ID | ENSG00000047315 |
| Bio databases IDs | |
| Aliases | RNA polymerase II subunit B |
| Synonyms | hRPB140, MGC47046, POL2RB, polymerase (RNA) II (DNA directed) polypeptide B, RNA polymerase II subunit B, Rpb140, RPB2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ricin-type beta-trefoil lectin domain
- DNA-directed RNA polymerase
- RNA_pol_B_RPB2
- chromatin binding
- enzyme
- protein binding
- RNA polymerase beta subunit
- RNA polymerase Rpb2, domain 4
- DNA binding
- RNA polymerase Rpb2, domain 5
- RNA-directed RNA polymerase
- RNA polymerase Rpb2, domain 6
- RNA polymerase Rpb2, domain 3
- RNA polymerase Rpb2, domain 2
- DNA-directed RNA polymerase subunit B
- RNA polymerase Rpb2, domain 7
- DNA-directed RNA polymerase, beta subunit
Pathways
Biological processes and signaling networks where the POLR2B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital heart disease
- breast carcinoma
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
regulates
- DNA promoter
- DNA endogenous promoter
- histone H3
- RNA polymerase II
- TP53
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, RNA-dependent
- transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- membrane
- nucleoplasm
- DNA-directed RNA polymerase II, core complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA polymerase II activity
- ribonucleoside binding
- RNA binding
- protein binding
- DNA-directed RNA polymerase activity
- metal ion binding
- RNA-directed RNA polymerase activity
- chromatin binding
- hydrolase activity