SLC5A10 Gene Summary [Human]

This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Details

Type
Protein Coding
Official Symbol
SLC5A10
Official Name
solute carrier family 5 member 10 [Source:HGNC Symbol;Acc:HGNC:23155]
Ensembl ID
ENSG00000154025
Bio databases IDs NCBI: 125206 Ensembl: ENSG00000154025
Aliases solute carrier family 5 member 10
Synonyms C330021F16Rik, SGLT-5, solute carrier family 5 member 10, solute carrier family 5 (sodium/glucose cotransporter), member 10
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC5A10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • cation:sugar symporter
  • mannose transporter
  • Solute carrier families 5 and 6-like; solute binding domain
  • fructose transporter
  • solute:sodium symporter
  • transporter

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hepatic steatosis
  • hyperalbuminemia
  • androgenic alopecia
regulated by
  • cisplatin
  • PKD1
  • methotrexate
  • doxorubicin
  • ifosfamide
  • MAFB
  • MAFA
regulates
  • triacylglycerol
  • Ins1
  • hexose
  • D-fructose
  • 1,5-anhydroglucitol
  • GPT
role in cell
  • transport in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Plasma Membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SLC5A10 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • mannose transport
  • sodium ion transmembrane transport
  • fructose transport
  • hexose transport

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • plasma membrane
  • apical plasma membrane

Molecular Function

What the gene product does at the molecular level
  • solute:sodium symporter activity
  • glucose:sodium symporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.