ASB11 Gene Summary [Human]
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Details
| Type | Protein Coding |
| Official Symbol | ASB11 |
| Official Name | ankyrin repeat and SOCS box containing 11 [Source:HGNC Symbol;Acc:HGNC:17186] |
| Ensembl ID | ENSG00000165192 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and SOCS box containing 11 |
| Synonyms | 1110067L12Rik, 1600009D24Rik, ankyrin repeat and SOCS box-containing 11, RGD1566298 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ASB11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- transcription regulator
- Ankyrin repeats (many copies)
- protein binding activity, bridging
- Ankyrin repeats (3 copies)
- SOCS
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
role in cell
- apoptosis
- ubiquitination in
- splicing in
- K48 polyubiquitination in
- turnover in
- endoplasmic reticulum stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ASB11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein catabolic process
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosol
- endoplasmic reticulum